Microbes and Behavior
Concerning the chemotherapeutic of microbial management of microbial disease, the most important changes surrounding the practice are based considerably on the novel information derived from the study of communication within cells on a microbial level. The understanding surrounding cell communication in bacteria has undergone a significant dynamic over the years. Currently, studies show that bacteria of disparate species as well as bacteria and the host are capable of detecting and responding to the chemical signals released by each entity (Sifri 1073). This new information has established significance concerning the inhibition of quorum sensing especially in therapeutic applications.
The new informational changes regarding the chemotherapeutic applications of microbial disease via management associate significantly with the innovations regarding communication between cells at the microbial level. In fact, new information surrounding the practice shows that the aspect of cell communication at the bacterial level is intrinsically related to the discoveries evident in intracellular bacterial communication and cooperative behaviors. Accordingly, pathogenic elements do not engage in a singular conversation with the affected host (Sifri 1075). This plurality in communication allows therapeutic applications to exploit intracellular communication in the management of microbial disease.
One imperative aspect surrounding the innovations in cell communication as well as the management of microbial level at a cellular level involves the novel significance that biofilm bears in the respective practices. Accordingly, microbial biofilm possesses a considerable effect on the treatment of infectious diseases due to their resistance to antimicrobial medication (Sifri 1074). In this respect, they are hard to eliminate with normal antimicrobial therapy. Additionally, the cell makeup of biofilms may actually be capable of carrying bacterial genes through the presence of bacteriophages. Lastly, the development of microbial biofilm acts as a breeding platform of chronic infections and ailments.
Sifri, Costi. D. “Healthcare Epidemiology: Quorum Sensing: Bacteria Talk Sense.” Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 47.8 (2008): 1070-6. Print.